THE COMBINATION OF HIGH FAT DIET AND MONOSODIUM GLUTAMATE ALTERING ADIPOGENESIS, BRAIN RESISTIN AND SERUM CORTISOL LEVEL IN FEMALE RAT

Home / Archives Vol. 8 No. 2 (2022): July Research Article THE COMBINATION OF HIGH FAT DIET AND MONOSODIUM GLUTAMATE ALTERING ADIPOGENESIS, BRAIN RESISTIN SERUM CORTISOL LEVEL IN FEMALE RAT Authors Aris Widayati Department of Physiology, Faculty Medicine, Universitas Brawijaya, Malang, Indonesia Dewi Mustika Yhusi Karina Riskawati Agustin Iskandar Parasitology, Nia Kurnianingsih DOI: https://doi.org/10.21776/ub.mnj.2022.008.02.8 Keywords: glutamate, fat diet, inflammation, behavior, BDNF Abstract Background: The prevalence obesity is increasing tremendously worldwide. Obesity correlated with the consumption a high-fat diet (HFD) and monosodium glutamate (MSG). Although effect MSG or HFD on inflammation has been established, lack information about effects both combination simultaneous systemic brain that can be evaluated from cortisol serum resistin level respectively. Objectives: This study aimed to investigate combining resistin, cortisol, lipid profiles, visceral weight, body weight gain. Methods: Sixteen adult female rats were randomized into 4 groups consist standard diet; HFD+MSG 0.05 mg/gBW, 0.2 mg/gBW 0.35 mg/gBW. Lipid profiles measured using automatic biochemical analyzer. Brain determined enzyme-linked immunoassay. Results: significantly have higher (p<0.003), (p<0.01), total cholesterol (p<0.003) (p<0.05) than control group. Conclusion: HFD, generates led systemic-brain alteration inflammation. Further necessary evaluate further functional impact combinations behavioral profiles.